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Patients who were non–transplant eligible, newly diagnosed with multiple myeloma (NDMM) and frail have inferior overall survival (OS), primarily because of treatment discontinuation due to toxicity. Therefore, evaluation of less-toxic effective therapies, such as the oral proteasome inhibitor ixazomib (Ixa) and the monoclonal anti-CD38 antibody daratumumab (Dara), is critical for this patient population as well as the elderly. Read More ›

The CANDOR trial was a randomized, open-label, phase 3 study in which carfilzomib, dexamethasone, and daratumumab were compared with carfilzomib and dexamethasone (Kd) for the treatment of patients with relapsed/refractory multiple myeloma (RRMM) who had undergone 1 to 3 prior lines of therapy. Read More ›

In patients with relapsed/refractory multiple myeloma (RRMM), although promising efficacy and acceptable toxicity were reported for belantamab mafodotin plus pomalidomide and dexamethasone, the high dose rate holds at the 2.5-mg/kg dose level were deemed to warrant examination of alternative-dosing schedules. Read More ›

Because multiple myeloma is a progressive disease and requires continued successive therapies, and there are few treatment options for patients who are refractory to anti-CD38 monoclonal antibodies, new therapies are needed. Read More ›

Results from a phase 3 study of a circularly permuted tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) combined with thalidomide and dexamethasone showed this was a safe and effective treatment for patients with relapsed/refractory multiple myeloma (RRMM), including those with a poor prognosis. Read More ›

The GMMG-HD6 study, an ongoing phase 3, randomized, open-label, multicenter trial, examines the effect of bortezomib, lenalidomide, and dexamethasone (VRD) with or without the addition of elotuzumab as induction therapy for newly diagnosed transplant-eligible patients with multiple myeloma (MM). Read More ›

Patients with light chain (AL) amyloidosis who were previously treated found encouraging efficacy and a good safety profile based on preliminary results from a phase 2 study of isatuximab. Read More ›

According to the IKEMA study interim analysis, isatuximab (Isa) plus carfilzomib and dexamethasone (Isa-Kd) resulted in a clinically meaningful improvement in depth of response; more patients reached minimal residual disease (MRD)-negative status when compared with those patients who received carfilzomib and dexamethasone alone. Read More ›

Both this retrospective analysis of the ICARIA-MM study data and the phase 1b TCD14079 study data aimed to evaluate the efficacy of isatuximab (Isa) with pomalidomide-dexamethasone (Pd) in patients with relapsed/refractory multiple myeloma (RRMM) with the gain(1q21) chromosomal abnormality. Read More ›

The ongoing GMMG-Concept trial is a phase 2, multicenter, investigator-initiated, open-label trial examining the induction, consolidation, and maintenance treatment of the 4-drug combination of isatuximab plus carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in patients newly diagnosed with high-risk multiple myeloma (MM); this includes both transplant-eligible and non–transplant-eligible patients. Read More ›

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