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February 2021, Vol 11, No 2

The treatment of renal-cell carcinoma (RCC) continues to evolve with the development of more effective frontline regimens. During the virtual 2020 International Kidney Cancer Symposium, experts discussed the expanding role of several of these therapies, including tyrosine kinase inhibitors (TKIs) and immunotherapies, which are being evaluated in various combinations to improve outcomes for patients with advanced and high-risk disease. Read More ›

On February 3, 2021, the FDA accelerated the approval of tepotinib (Tepmetko; EMD Serono), an oral MET kinase inhibitor, for the treatment of patients with metastatic non–small-cell lung cancer (NSCLC) who harbor MET exon 14 skipping alterations. Read More ›

On January 22, 2021, the FDA approved the combination of nivolumab (Opdivo; Bristol Myers Squibb), an immune checkpoint inhibitor, and cabozantinib (Cabometyx; Exelixis), a tyrosine kinase inhibitor, for the first-line treatment of patients with advanced renal-cell carcinoma. Read More ›

On January 14, 2021, the FDA approved crizotinib (Xalkori; Pfizer), an oral tyrosine kinase inhibitor, for the treatment of pediatric patients aged ≥1 years and young adults with relapsed or refractory systemic ALK-positive anaplastic large-cell lymphoma (ALCL). The safety and efficacy of crizotinib have not been established in older adults with relapsed or refractory systemic ALK-positive ALCL. Read More ›

The following clinical trials represent a selection of key studies currently recruiting patients with gynecologic cancers for inclusion in investigations of new therapies and new regimens of existing treatments for the disease. Each clinical trial description includes the NLM Identifier to be used as a reference with ClinicalTrials.gov. This information can help oncology practice managers and providers direct eligible patients to one of these clinical trials. Read More ›

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