In the Literature

Second-line standard therapy for patients with relapsed or refractory large B-cell lymphoma is high-dose chemotherapy and autologous stem-cell transplantation (ASCT), but the prognosis after first-line therapy is poor for many patients, who are unable to receive definitive therapy. Read More ›

First-line chemotherapy is the standard of care for advanced esophageal SCC, but survival outcomes are poor. First-line combination immunotherapy with the PD-1 inhibitor nivolumab (Opdivo) plus the CTLA-4 inhibitor ipilimumab (Yervoy) led to longer overall survival (OS) than chemotherapy or nivolumab monotherapy in solid tumors. Read More ›

The number of women screened for cervical cancer in the United States declined between 2005 and 2019, with lack of knowledge about the need for screening cited as the primary reason for not being up to date, according to findings from a recent population-based, cross-sectional study. Read More ›

Nivolumab (Opdivo) has been shown to have antitumor activity in patients with metastatic urothelial carcinoma who received platinum treatment. However, the role of this agent as adjuvant therapy in high-risk muscle-invasive urothelial carcinoma following surgery has been unclear. In a recent study, researchers evaluated the efficacy and safety of adjuvant nivolumab compared with placebo in patients with muscle-invasive urothelial carcinoma following radical surgery (Bajorin DF, et al. N Engl J Med. 2021;384:2102-2104). Read More ›

Sacituzumab govitecan (Trodelvy), a Trop-2 antibody and topoisomerase inhibitor, showed promising results in a small clinical trial of patients with metastatic TNBC. These findings provided the basis for accelerated FDA approval of this agent in April 2020 for the treatment of patients with metastatic TNBC who have received ≥2 previous therapies in the metastatic setting, with full approval contingent on the results of the confirmatory phase 3 ASCENT study (Bardia A, et al. N Engl J Med. Read More ›

It is estimated that in 2020, there were 6.3 million cases and 3.3 million deaths globally of mouth, pharynx, larynx, esophageal, colon, rectum, liver, and breast cancer. These cancers have causal links to alcohol consumption. However, patterns of alcohol use continue to change over time across the world. With changes in alcohol consumption and more recent cancer incidence data, new estimates of the alcohol-attributable burden of cancer are needed. Read More ›

Regular aspirin use is considered the best chemoprevention strategy to reduce colorectal cancer (CRC) risk in middle-aged adults. This supported the US Preventive Services Task Force’s (USPSTF) recommendation of daily aspirin for CRC prophylaxis in adults aged 50 to 59 years and certain cardiovascular risk factors. The USPSTF, however, also recommends aspirin use in people aged ≥70 years, but the evidence for this is inconsistent. Read More ›

Esophageal cancer is a leading cause of cancer-related morbidity and mortality worldwide. Chemoradiotherapy followed by surgery is the standard of care for patients with resectable, locally advanced esophageal cancer. However, the risk for recurrence after this treatment remains high, especially among the majority of patients who do not have a pathologic complete response. Read More ›

Previous analyses have pointed to alarming shortages of oncology providers in the face of growing demand. No oncology workforce study, however, has assessed the link between geographic need for oncology services and the codependency between oncologists and nonphysician health professionals with an oncology subspecialty. A recent report on the state of cancer care in the United States examined the availability of physicians and oncology pharmacists and their geographic distributions throughout the country and compared it with the need for oncology services in each county. Read More ›

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