Cholangiocarcinoma

In the JCOG1202 subgroup analysis, researchers analyzed risk factors for early relapse in patients with biliary tract cancer undergoing surgical resection. Read More ›

Researchers aimed to assess characteristics, outcomes, and genomic profiles of long-term survivors treated with durvalumab plus gemcitabine/cisplatin (GemCis) or placebo plus GemCis in the TOPAZ-1 trial. Read More ›

IMbrave 151 examined the efficacy of the PD-L1 inhibitor atezolizumab with or without the VEGF inhibitor bevacizumab, and gemcitabine/cisplatin as first-line treatments in patients with advanced biliary tract cancer. Read More ›

A single-arm, phase 2 study investigated the safety and efficacy of second-line nab-paclitaxel combined with the anti–PD-1 antibody sintilimab in patients with advanced biliary tract cancer. Read More ›

This phase 2 randomized trial assessed stereotactic body radiation and the anti–PD-1 drug nivolumab with or without the anti-CTLA4 drug ipilimumab in patients with metastatic biliary tract cancer. Read More ›

This study examined the costs of treatment with gemcitabine/cisplatin with or without durvalumab in patients with advanced cholangiocarcinoma. Read More ›

In the phase 3 Nutide:121 study, NUC-1031 plus cisplatin was compared with gemcitabine/cisplatin for first-line treatment of patients with advanced biliary tract cancer. Read More ›

At the 10th Annual Cholangiocarcinoma Foundation Conference, Rachna Shroff, MD, MS, Chief, Gastrointestinal Medical Oncology, and Director, Clinical Trials Office, University of Arizona Cancer Center, Tucson, and Madhulika Eluri, MD, Hematology/Oncology Fellow, The University of Texas MD Anderson Cancer Center, Houston, debated whether chemotherapy remains the backbone for cholangiocarcinoma (CCA) treatment or if it is time to move away from this therapeutic strategy. Read More ›

At the 10th Annual Cholangiocarcinoma Foundation Conference, Michael E. Lidsky, MD, Assistant Professor, Surgical Oncology, Duke University School of Medicine, Durham, NC, presented his research on a novel model to investigate FGFR signaling and how this information may lead to a new treatment strategy for FGFR2 fusion–positive cholangiocarcinoma (CCA). For patients with advanced CCA, surgery is often not an option, and patients are left with systemic therapy as the only treatment option. Read More ›

Over the years, the therapeutic landscape for cholangiocarcinoma (CCA) has expanded beyond chemotherapy to include immunotherapy and targeted therapies as part of an individualized approach to treatment. At the 10th Annual Cholangiocarcinoma Foundation Conference, Tim F. Greten, MD, Deputy Chief, Thoracic and GI Malignancies Branch; Head, Gastrointestinal Malignancy Section; and Co-Director, National Cancer Institute Center for Cancer Research Liver Cancer Program, Bethesda, MD, discussed novel targets for future CCA treatments coming from translational research studies. Read More ›