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Cholangiocarcinoma
The International Cholangiocarcinoma Research Network Program Initiatives
Cholangiocarcinoma
May 2022, Vol 12, No 5
The International Cholangiocarcinoma Research Network (ICRN) is a program initiated by the Cholangiocarcinoma Foundation (CCF). The core mission of this network of international experts is “to rapidly translate scientific discoveries into practice for cholangiocarcinoma patients through a collaborative, highly translational international research network.
Read More ›
The Cholangiocarcinoma Foundation’s Patient Advocacy Initiatives
Cholangiocarcinoma
May 2022, Vol 12, No 5
At the 2022 Cholangiocarcinoma Foundation (CCF) Annual Conference on Melinda Bachini, Director of Advocacy of CCF, provided an update on the foundation’s advocacy and patient support initiatives.
Read More ›
Expert Perspective on the Evolving Standard of Care in Biliary Tract Cancers
By
Erin Burns, PhD
Cholangiocarcinoma
February 2022, Vol 12, No 2
Mitesh J. Borad, MD, Mayo Clinic College of Medicine and Science, Phoenix, AZ, delivered an expert Keynote Perspective at the Third Annual CCA Summit, highlighting genomic profiling as the standard of care in the management of patients with intrahepatic cholangiocarcinoma (CCA), with liquid biopsy becoming the tool of choice for genomic profiling in biliary tract cancers.
Read More ›
Molecular Epidemiology of Cholangiocarcinoma: Identifying New Inherited Variants
By
Erin Burns, PhD
Cholangiocarcinoma
January 2022, Vol 12, No 1
Cholangiocarcinoma (CCA) involves genetic heterogeneity, highlighting the need to identify new inherited variants, as discussed at the 3rd Annual CCA Summit in Session II, “Molecular Epidemiology of CCA.”
Read More ›
Navigating Compassionate Use Options for Your Patients with Cholangiocarcinoma
By
Melinda Bachini
Cholangiocarcinoma
November 2021, Vol 11, No 11
I believe that the most powerful and positive force in medicine is that of a self-advocating patient. At the Cholangiocarcinoma Foundation, we strive to connect, educate, and empower patients with cholangiocarcinoma (CCA) to partner with their care team in navigating the course of their treatment. However, we understand that the treatment options are extremely limited for many patients with CCA.
Read More ›
Role of Radiology in Intrahepatic Cholangiocarcinoma Addressed at 2 Interventional Oncology and Radiology Meetings
Cholangiocarcinoma
October 2021, Vol 11, No 10
Key topics related to intrahepatic cholangiocarcinoma (CCA) were presented at the 2021 Society of Interventional Oncology (SIO) and the Society of Interventional Radiology (SIR) meetings and were discussed at the CCA Summit. Bruno C. Odisio, MD, FSIR, Interventional Radiologist and Co-Director of Research, Interventional Radiology, M.D. Anderson Cancer Center, Houston, TX, reviewed the findings.
Read More ›
Truseltiq Received FDA Approval for Metastatic CCA with FGFR2 Mutation
Cholangiocarcinoma
,
FDA Approvals, News & Updates
July 2021, Vol 11, No 7
On
May 28, 2021
, the FDA granted accelerated approval to infigratinib (Truseltiq; QED Therapeutics, Inc), an oral
FGFR1-3
selective inhibitor, for the treatment of adults with previously treated locally advanced or metastatic cholangiocarcinoma (CCA) with an
FGFR2
fusion or other rearrangement. The FDA previously granted infigratinib orphan drug and fast-track designations.
Read More ›
Ivosidenib Extends Survival in Patients with Cholangiocarcinoma and IDH1 Mutation
By
Wayne Kuznar
ASCO GU Cancers Highlights
,
Cholangiocarcinoma
April 2021, Vol 11, No 4
Final results from the phase 3 clinical trial ClarIDHy showed that ivosidenib (Tibsovo), a first-in-class oral inhibitor of isocitrate dehydrogenase 1 (
IDH1
) mutation, prolonged the median overall survival (OS) in patients with previously treated advanced cholangiocarcinoma (CCA) and
IDH1
mutation. Although this improvement did not reach statistical significance, after adjusting for crossovers from the placebo group to the ivosidenib group, the difference in median OS improvement was statistically significant.
Read More ›
Targeted Therapies in Cholangiocarcinoma
Cholangiocarcinoma
March 2021, Vol 11, No 3
The recent FDA approval of the first
FGFR
inhibitor, pemigatinib (Pemazyre), and the positive results from the phase 3 study of the first
IDH1
inhibitor, ivosidenib (Tibsovo), represent major breakthroughs in the treatment of patients with cholangiocarcinoma (CCA), a rare cancer associated with poor outcomes. However, the duration of response with these agents is still relatively short.
Read More ›
Combination of NUC-1031 plus Cisplatin Shows Promise as First-Line Treatment for Advanced Biliary Tract Cancer
By
Eileen Koutnik-Fotopoulos
Cholangiocarcinoma
May 2020, Vol 10, No 5
Cholangiocarcinoma (CCA), a type of biliary tract cancer, is a rare malignancy, with no FDA-approved medications specifically for this type of cancer. The current standard first-line treatment for patients with locally advanced or metastatic CCA is a chemotherapy combination of gemcitabine and cisplatin.
Read More ›
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