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2020 Year in Review - Neuroendocrine Tumors

Findings of a retrospective analysis suggest that patients with well-differentiated metastatic/unresectable grade 3 gastroenteropancreatic neuroendocrine tumors (GEP-NETs) may derive modest progression-free survival (PFS) benefit with somatostatin analog (SSA) monotherapy. Read More ›

Findings of a comparative real-world analysis of long-acting somatostatin analogs (SSAs) indicate that lanreotide was associated with lower injection burden, use of rescue medications, and cost. Read More ›

Results of the randomized, open-label phase 2 Australasian Gastrointestinal Trials Group CONTROL NET study indicate that capecitabine/temozolomide (CAPTEM) plus 177Lu-octreotate peptide receptor radionuclide therapy (PPRT) combination treatment was active and well-tolerated compared with CAPTEM or PPRT alone in patients with pancreatic neuroendocrine tumors (pNETs) and updated midgut neuroendocrine tumors (mNETs). Read More ›

Real-world data from a retrospective analysis of octreotide long-acting release (LAR) dosing patterns on treatment persistence in patients with symptomatic metastatic neuroendocrine tumors (NETs) indicate that physician experience and treatment at tertiary centers has a significant impact on dose selection and treatment persistence. Read More ›

Findings of a comparative retrospective analysis indicate that first-line octreotide long-acting release (LAR) and lanreotide treatment was associated with similar progression-free survival (PFS) and biochemical response in patients with metastatic, well-differentiated metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Read More ›

Results of a placebo-controlled, randomized phase 2 trial indicate that maintenance treatment with lanreotide autogel (LAN) following first-line treatment may provide clinical benefit in aggressive grade 1 and 2, well-differentiated, duodeno-pancreatic neuroendocrine tumors (NETs). Read More ›


Preliminary results of an ongoing dose-escalation and expansion phase 1 (Duet 1; NCT03411915) trial indicate that the anti–somatostatin receptor type 2 (SSTR2) × anti-CD3 bispecific antibody XmAb18087 was well-tolerated and accompanied by sustained T-cell activation in patients with advanced neuroendocrine tumors (NETs). Read More ›

A retrospective analysis of a large database of grade 3 gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) identified clinically relevant prognostic factors that could potentially inform clinical decisions in this setting. Read More ›

Results of a retrospective analysis of first-line chemotherapy regimens indicate that non–platinum/etoposide regimens may provide a significant progression-free survival (PFS) benefit versus platinum/etoposide regimens for patients with grade 3 neuroendocrine tumors (NETs). Read More ›

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