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Medications Used in the Treatment of Thyroid Cancer and the Associated ICD-10 Codes

Cancer Drug Coding, ICD Codes, Reimbursement
Kristin A. Esposito, CPhT
Clinical Services Manager, RJ Health Systems

This detailed article of codes related to thyroid cancer is intended to assist practice managers and other healthcare providers and payers to ensure the proper use of coding and billing information associated with the treatment of patients with thyroid cancer.

The following sections include:
  • Associated ICD-10-CM codes used for the classification of thyroid cancer
  • Drugs that have been approved by the FDA for the treatment of thyroid cancer
  • Drugs for Compendia off-label uses have no FDA-approved uses in thyroid cancer. However, drugs that are FDA approved for at least one of the thyroid cancer ICD-10-CM codes may also have Compendia off-label uses
  • Drugs that are Compendia-listed for off-label use for thyroid cancer based on clinical studies that suggest beneficial use in some cases. Please note: If a check mark appears in the FDA column, it will NOT appear in the Compendia off-label use column
  • Corresponding HCPCS/CPT® codes and code descriptions
  • Possible CPT® administration codes for the drugs

Associated ICD-10-CM Codes

C73 Malignant neoplasm of thyroid gland
Generic (brand) name HCPCS code—code description FDA approved for thyroid cancer Compendia off-label uses for thyroid cancer Possible CPT® administration codes
bleomycin (Blenoxane) J9040 - Injection, bleomycin sulfate, 15 units   ✔ 96401, 96409
cabozantinib (Cometriq) *C9399 - Unclassified drugs or biological (Hospital outpatient use only) ✔   N/A
cabozantinib (Cometriq) *J8999 - Prescription drug, oral, chemotherapeutic, not otherwise specified ✔   N/A
cisplatin (Platinol AQ) J9060 - Injection, cisplatin, powder or solution, per 10 mg   ✔ 96409, 96413, 96415
doxorubicin HCl (Adriamycin) J9000 - Injection, doxorubicin hydrochloride, 10 mg ✔   96409
etoposide (Vepesid) J8560 - Etoposide, oral, 50 mg   ✔ N/A
etoposide (Etopophos, Toposar) J9181 - Injection, etoposide, 10 mg   ✔ 96413, 96415
interferon alfa-2b (Intron-A) J9214 - Injection, interferon, alfa-2b, recombinant, 1 million units   ✔ 96372, 96401
lanreotide (Somatuline Depot) J1930 - Injection, lanreotide, 1 mg   ✔ 96372
lenvatinib (Lenvima) *C9399 - Unclassified drugs or biological (Hospital outpatient use only) ✔   N/A
lenvatinib (Lenvima) *J8999 - Prescription drug, oral, chemotherapeutic, not otherwise specified ✔   N/A
levothyroxine (eg, Synthroid, Levoxyl) J8499* - Prescription drug, oral, nonchemotherapeutic, not otherwise specified ✔   N/A
sodium iodide I-131 A9517 - Iodine I-131 sodium iodide capsule(s), therapeutic, per millicurie ✔   N/A
sorafenib tosylate (Nexavar) *C9399 - Unclassified drugs or biological (Hospital outpatient use only) ✔   N/A
sorafenib tosylate (Nexavar) *J8999 - Prescription drug, oral, chemotherapeutic, not otherwise specified ✔   N/A
vandetanib (Caprelsa) *C9399 - Unclassified drugs or biological (Hospital outpatient use only) ✔   N/A
vandetanib (Caprelsa) *J8999 - Prescription drug, oral, chemotherapeutic, not otherwise specified ✔   N/A
*When billing a nonclassified medication using a CMS 1500 claim form you must include both the HCPCS code in Item 24D and the drug name, strength, and NDC (National Drug Code) in Box 19 or Item 24A (shaded area) in order to ensure appropriate reimbursement. Please note: Check with payer regarding correct placement of medication information.
References
• HCPCS Level II Expert 2016
• Current Procedural Terminology (CPT®) 2016
• CPT Copyright © 2016 American Medical Association. All rights reserved. CPT is a registered trademark of the American Medical Association
• ICD-10-CM for Professionals Volumes 1 & 2 2016
• FDA-approved indication (product Prescribing Information)
• Compendia references available upon request
• www.ReimbursementCodes.com powered by RJ Health Systems International, LLC, Rocky Hill, CT
• CMS (Centers for Medicare & Medicaid Services)
G-CSF indicates granulocyte colony-stimulating factor; HCPCS, Healthcare Common Procedure Coding System.
This information was supplied by
30 Cold Spring Road, Rocky Hill, CT 06067 • T: (860) 563-1223 F: (860) 563-1650

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