Breast Cancer

Preclinical data demonstrated that tucatinib potentiates the activity of T-DM1 in HER2+ breast cancer models in vitro and in vivo, and enhances the activity of a camptothecin-based HER2 antibody-drug conjugate comprised of trastuzumab conjugated with 8 exatecan moieties. Read More ›

Shanu Modi, MD, provided an overview of promising novel therapies in development for the treatment of refractory HER2+ metastatic breast cancer. Read More ›

Results from the phase 2 PATRICIA study suggest pertuzumab plus high-dose trastuzumab may have clinical utility in some patients with HER2+ metastatic breast cancer (MBC) with progressive central nervous system (CNS) metastases. Read More ›

Results from the MetaPHER study showed the safety profile of first-line subcutaneous trastuzumab + intravenous (IV) pertuzumab and IV docetaxel for HER2+ advanced breast cancer was consistent with the known safety profile and efficacy data reported for IV trastuzumab + IV pertuzumab and IV docetaxel. Read More ›

The past week in oncology-related news includes shortages of crucial pediatric cancer drug, results of a study of racial disparities in multiple myeloma, and new drug on the horizon for HER2 metastatic breast cancer. Read More ›

The addition of the cyclin-dependent kinase (CDK)4/CDK6 inhibitor ribociclib to standard endocrine therapy significantly extended overall survival (OS) compared with endocrine therapy alone in premenopausal women with hormone receptor (HR)-positive, HER2-negative advanced breast cancer, according to results of the phase 3 MONALEESA-7 clinical trial, presented at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting. Read More ›

Two human genes, BRCA1 and BRCA2 (BRCA1/2), produce proteins that block the growth of cancer, such as breast or ovarian cancer. These proteins ensure the stability of each cell’s genetic material and help to repair damaged DNA. A mutation in either BRCA results in these proteins not functioning correctly. Specifically, DNA damage may not be repaired effectively, which can lead to cancer. Read More ›

Options for the treatment of patients with advanced hormone receptor (HR)-positive, HER2-negative breast cancer are expanding. The updated National Comprehensive Cancer Network (NCCN) guideline (version 1.2019) for the management of invasive breast cancer is focused on HR-positive, HER2-­negative disease. William J. Gradishar, MD, Director, Maggie Daley Center for Women’s Cancer Care, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, discussed the updated guideline at the NCCN 2019 Conference. Read More ›

On February 28, 2019, the FDA approved a combination of the HER2/neu receptor agonist trastuzumab plus the endoglycosidase hyaluronidase-oysk (Herceptin Hylecta; Genentech) subcutaneous (SC) injection for adults with HER2-overexpressing breast cancer in the ad­­juvant setting, as part of a regimen with chemotherapy or as monotherapy after multimodality anthracycline-based therapy; and as first-line treatment for metastatic disease, in combination with paclitaxel, or as monotherapy after ≥1 chemotherapies in the metastatic setting. Read More ›

On April 4, 2019, the FDA approved a new indication for palbociclib (Ibrance; Pfizer), an oral kinase inhibitor, for men with hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer. Read More ›

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